Central Sensitization Syndromes


At the end of the last century, Dr. Muhammad B. Yunus, professor of Medicine at the University of Illinois (USA), was the first to include under the term Central Sensitization various processes that had in common a hyperexcitability and hypersensitivity of the nervous system and the immune system against infections, chemical products, electromagnetic fields, drugs, stress ...

All these processes were of unknown cause, shared a similar physiopathology and numerous symptoms: fatigue that does not recover with rest, pain that does not have specific damage associated, repetitive infections, cognitive alterations (mental slowness, lack of concentration and memory), non-restorative sleep, gastrointestinal alterations (without apparent cause to justify them), hypersensitivity to various chemical substances and electromagnetic fields that causes hyperresponsiveness to these, and that remains over time despite the disappearance of the stimulus that generated it.

The term Central Sensitization Syndromes (CSS) encompasses processes such as fibromyalgia (FM), chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), irritable bowel/colon syndrome, restless legs syndrome, interstitial cystitis, some temporary headaches and migraines, among others. More recently, multiple chemical sensitivity (MCS) and electrohypersensitivity (EHS) have also been added.

These syndromes, which present numerous common symptoms, overlap in a high percentage of patients. In fact, there are numerous studies that show that the majority of people who have one of these diseases, may end up having the others in greater or lesser degree of affectation.

In any case, the relationship between these pathologies is evident, both with regard to common symptoms, as for the life experience of most people who suffer them.

The information contained in this website is intended to complement, and not to replace, in any case, the information and assistance of health professionals.


Fibromyalgia (FM)

Chronic Fatigue Syndrome (CFS/ME)

Multiple Chemical Sensitivity (MCS)

Electro Hypersensitivity (EHS)


More information on Central Sensitization Syndromes:





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